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KMID : 0605720160220030237
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Journal of the Korean Society of Biological Therapies in Psychiatry
2016 Volume.22 No. 3 p.237 ~ p.245
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Association of Restless Legs Syndrome with Depression, Anxiety, and Insomnia in Patients with Obstructive Sleep Apnea Syndrome
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Kim Ju-Wan
Kim Sung-Wan
Kim Jae-Min
Shin Il-Seon
Yoon Jin-Sang
Bae Kyung-Yeol
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Abstract
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Objectives：An association between obstructive sleep apnea syndrome(OSAS) and restless legs syndrome(RLS) has long been reported. Both syndromes are associated with depression, anxiety, insomnia, and daytime sleepiness. However, these relationships have not been studied extensively, and many questions remain unanswered. This study investigated the prevalence of RLS and its association with depression, anxiety, insomnia, and daytime sleepiness in OSAS patients in Korea.
Methods：The study enrolled 152 Korean OSAS in patients Chonnam National University Hospital. The International Restless Legs Syndrome Study Group criteria and International Restless Legs Scale were used to determine the diagnosis and severity of RLS. To assess depression, anxiety, insomnia, and day time sleepiness, all patients completed the Beck Depression Inventory(BDI), Beck Anxiety Inventory(BAI), Insomnia Severity Index(ISI), and Epworth Sleepiness Scale(ESS).
Results：Overall, 65(42.6%) patients met least one of the RLS diagnostic criteria, and 17(11.1%) were diagnosed with RLS. The mean BDI, BAI, and ISI scores were higher in subjects with RLS symptoms compared with those without such symptoms. ESS scores were not significantly associated with RLS symptoms. There were significant positive correlations between RLS severity and BDI(r=0.246, p=0.049), BAI(r=0.247, p=0.031), and ISI(r=0.275, p=0.026) scores.
Conclusion：There were significant relationships between RLS symptoms and depression, anxiety, and insomnia. We recommend that patients with OSAS be evaluated for symptoms of RLS.
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KEYWORD
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Obstructive sleep apnea syndrome, Restless legs syndrome, Depression, Anxiety, Insomnia
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